What question did this study set out to answer?

To examine the functional involvement of histidine amino acid residues within sarcoplasmic reticulum membrane proteins during calcium ion transport and related biochemical activities.

December 1, 1974Biochemistry

Functioning of histidine residues of sarcoplasmic reticulum in calcium(2+) ion transport and related activities

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Authors

BYByung P. YuThe University of Texas Health Science Center at San Antonio EMEdward J. MasoroTufts University HBH. A. BertrandTexas Biomedical Research Institute

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Implication

No immediate clinical implications; leaves open mechanistic studies of histidine in cardiac calcium handling.

Key Points

To examine the functional involvement of histidine amino acid residues within sarcoplasmic reticulum membrane proteins during calcium ion transport and related biochemical activities.
Assayed isolated sarcoplasmic reticulum membrane fractions under defined in vitro biochemical conditions.
Evaluated the relationship between histidine residue functional status and active calcium ion translocation.
Histidine residues within sarcoplasmic reticulum components functionally support the active transport of calcium ions.
Chemical integrity of these specific amino acid sites corresponds directly with optimal calcium-dependent membrane functional activity.

Cite This Study

Yu et al. (1974) studied this question.

synapsesocial.com/papers/6a716fe42163a0a01bc59549 https://doi.org/10.1021/bi00722a004

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Functioning of histidine residues of sarcoplasmic reticulum in calcium(2+) ion transport and related activities

Discussion

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Implication

Key Points

Cite This Study

Functioning of histidine residues of sarcoplasmic reticulum in calcium(2+) ion transport and related activities

Discussion

Member takes

Implication

Key Points

Cite This Study

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