Why the study?
Does enalapril compared to verapamil and placebo alter renal hemodynamic and tubular effects in patients with essential hypertension?
Population
15 patients with established essential hypertension
Comparison
Enalapril 40 mg once daily for 2 months vs Verapamil slow release 240 mg twice daily for 2…
Design
RCT, Crossover design, Double-blind, double-dummy, placebo-controlled
Follow-up
2 months per treatment period
Authors
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Either agent safely lowers BP without reducing GFR in essential hypertension; extends evidence on verapamil's distinct renal hemodynamic effects.
Does enalapril compared to verapamil and placebo alter renal hemodynamic and tubular effects in patients with essential hypertension?
Both enalapril and verapamil effectively lower blood pressure in essential hypertension while preserving renal hemodynamic and tubular function.
Katzman et al. (1990) studied this question.
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