Sex-related in vitro/in vivo and PK/PD correlations after oral single dose furosemide administration

Introduction Furosemide is a loop diuretic that is commonly used in the treatment of edematous states associated with cardiac, renal, hepatic failure and in the treatment of uncontrolled hypertension with abnormal renal function. Its oral bioavailability is low (67%) even if a solution of 40 mg is given to healthy male subjects [1].