What question did this study set out to answer?

Review the molecular, genetic, and metabolic heterogeneity underlying familial combined hyperlipidemia and its relationship to coronary artery disease.

April 1, 1993Current Opinion in Lipidology

Genetics and molecular biology of familial combined hyperlipidemia

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Population

Patients with familial combined hyperlipidemia (FCHL) and related syndromes

Design

Review

Authors

PKPeter O. KwiterovichGeneral / Preventive / Lipids

Discussion

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Implication

Does not yet change FCHL management; leaves open targeted genetic investigations into CAD pathways.

Key Points

Review the molecular, genetic, and metabolic heterogeneity underlying familial combined hyperlipidemia and its relationship to coronary artery disease.
Synthesized molecular genetics and metabolic findings evaluated across eight putative candidate loci.
Assessed related dyslipidemic phenotypes including hyperapobetalipoproteinemia, LDL subclass pattern B, familial dyslipidemic hypertension, and syndrome X.
Identified substantial genetic and metabolic heterogeneity tied to eight putative gene loci implicated in disease etiology.
Established shared phenotypic characteristics between familial combined hyperlipidemia and interrelated metabolic syndromes that predispose individuals to premature coronary atherosclerosis.

Structured PICO

Population

Patients with familial combined hyperlipidemia (FCHL) and related syndromes

Understanding the genetic and molecular heterogeneity of familial combined hyperlipidemia may provide insights into the pathophysiology of coronary artery disease.

Cite This Study

Peter O. Kwiterovich (1993) studied this question.

synapsesocial.com/papers/6a7170ec6c240de38cdc241c https://doi.org/10.1097/00041433-199304000-00009

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Genetics and molecular biology of familial combined hyperlipidemia

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Genetics and molecular biology of familial combined hyperlipidemia

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider