Why the study?
Does being heterozygous for factor V Leiden affect the livebirth rate in women with recurrent miscarriage compared to those with unexplained recurrent miscarriage?
Does being heterozygous for factor V Leiden affect the livebirth rate in women with recurrent miscarriage compared to those with unexplained recurrent miscarriage?
Untreated pregnancies in women with recurrent miscarriage who are heterozygous for factor V Leiden have a statistically similar livebirth rate to those with unexplained recurrent miscarriage.
Similar livebirth rates in FVL carriers and unexplained RM; leaves open utility of thrombophilia testing in recurrent miscarriage.
We compared the outcome of 25 untreated pregnancies among women with recurrent miscarriage (RM) at <12 weeks' gestation who were heterozygous for factor V Leiden with women with unexplained RM. The livebirth rate was lower among pregnancies in carriers of factor V Leiden (12/25; 48%) compared with pregnancies in women with unexplained RM (175/307; 57%), but the difference did not reach statistical significance. The best possible treatment regimen to improve livebirth rate in this group of women needs to be assessed in the form of a randomised controlled trial.
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Jivraj et al. (2009) studied this question.
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