Key result
Maternal factor V Leiden genotype is associated with increased risks of isolated third trimester fetal loss (OR 2.4; 95% CI 1.1-5.2), severe preeclampsia (OR 2.9), and fetal growth retardation.
Why the study?
Is maternal factor V Leiden genotype associated with an increased risk of adverse pregnancy outcomes?
Population
Pregnant women in cohort or case-control studies evaluating adverse pregnancy outcomes
Comparison
Maternal factor V Leiden mutation vs Absence of maternal factor V Leiden mutation
Design
Meta-analysis
Authors
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May inform selective testing after recurrent third-trimester loss; leaves open whether screening improves outcomes in prospective trials.
Meta-Analysis
Is maternal factor V Leiden genotype associated with an increased risk of adverse pregnancy outcomes?
Odds Ratio: 2.4 (95% CI 1.1–5.2)
Maternal factor V Leiden mutation is significantly associated with increased risks of second/third trimester fetal loss, severe preeclampsia, and fetal growth retardation, supporting testing in women with recurrent or third-trimester fetal loss.
Attia et al. (2004) conducted a meta-analysis in Adverse pregnancy outcomes. Maternal factor V Leiden genotype vs. Absence of factor V Leiden mutation was evaluated on Isolated (non-recurrent) third trimester fetal loss (OR 2.4, 95% CI 1.1-5.2). Maternal factor V Leiden genotype is associated with increased risks of isolated third trimester fetal loss (OR 2.4; 95% CI 1.1-5.2), severe preeclampsia (OR 2.9), and fetal growth retardation.
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