Key result
Factor V Leiden is a genetic mutation linked to venous thromboembolism, preeclampsia, and pregnancy loss, for which thorough personal and family history is the most effective screening tool.
Factor V Leiden is an important genetic risk factor for venous thromboembolism and adverse pregnancy outcomes, highlighting the need for thorough history-based screening and patient counseling.
May support history-guided counseling in pregnancy; leaves open whether genetic testing improves outcomes.
Factor V Leiden, formed by a genetic mutation, disrupts the body's anticoagulation defense system. It was isolated as recently as 1994 as a risk factor for venous thromboembolism. Factor V Leiden has also been linked to preeclampsia, pregnancy loss, and fetal growth restriction. In addition, factor V Leiden has implications for women who are not pregnant. The most effective screening tool is a thorough personal and family history related to thrombosis. For women with a positive factor V Leiden screen, counseling regarding the risks of thrombosis is essential.
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Lynette A. Ament (2003) conducted a review in Factor V Leiden. Factor V Leiden was evaluated. Factor V Leiden is a genetic mutation linked to venous thromboembolism, preeclampsia, and pregnancy loss, for which thorough personal and family history is the most effective screening tool.
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