Key result
Selective factor V Leiden screening postpartum using a risk score identified women at high risk for thrombosis, with an estimated 83 women needing treatment to prevent one thrombotic episode.
Why the study?
Does selective factor V Leiden screening based on a clinical risk score identify postpartum women who would benefit from anticoagulant prophylaxis to prevent thrombosis?
Population
2,384 pregnant/postpartum women with known factor V Leiden status
Design
Cohort
Follow-up
postpartum period (6 weeks)
Authors
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Supports risk-stratified postpartum screening; hypothesis-generating and should not yet change practice.
Cohort (n=2,384)
Does selective factor V Leiden screening based on a clinical risk score identify postpartum women who would benefit from anticoagulant prophylaxis to prevent thrombosis?
Number Needed to Treat: 83
Number Needed to Treat: 83
A clinical risk score can identify a high-risk subgroup of postpartum women for whom selective factor V Leiden screening could effectively guide anticoagulant prophylaxis to prevent venous thromboembolism.
Pelle G. Lindqvist (2002) conducted a cohort in Pregnancy at risk for thrombosis (n=2,384). Selective factor V Leiden screening using a risk score was evaluated on Thrombotic episode (NNT 83). Selective factor V Leiden screening postpartum using a risk score identified women at high risk for thrombosis, with an estimated 83 women needing treatment to prevent one thrombotic episode.
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