Key result
Factor V Leiden was not associated with an increased risk of fetal loss, occurring in 10% of women with the mutation compared to 9% of women without it (p=0.1).
Why the study?
Does Factor V Leiden increase the risk of fetal loss in pregnant women?
Observational (n=155)
No
Does Factor V Leiden increase the risk of fetal loss in pregnant women?
Factor V Leiden was not found to be a significant risk factor for fetal loss, suggesting prophylactic anticoagulant treatment is not indicated for this specific indication in these carriers.
Answers are grounded in this paper and cite their sources.
No association in this cohort does not support changing anticoagulation practice; leaves open confirmation in larger prospective studies.
A successful pregnancy is dependent on the development of adequate placental circulation. The abnormalities of placental vasculature may result in a number of gestational pathologies, including fetal loss. The aim of our study was to determine whether women with f V Leiden are at an increased risk of pregnancy loss. For this purpose we assessed three groups of women. In a prospective group we examined 30 females with spontaneous abortions for f V Leiden. In a retrospective group we assessed the frequency of abortions in 80 women (172 pregnancies) with f V Leiden (72 heterozygous, 8 homozygous) from 57 unrelated families. In a control group we evaluated the frequency of abortions in 45 women without f V Leiden. Factor V Leiden was found in 3% of women in the 1st group. Fetal loss occurred in 10% of women in the 2nd group and in 9% in the 3rd group. Factor V Leiden was not found to be a risk factor for fetal loss in our study group.
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Ďulíček et al. (1999) conducted an observational in Fetal loss (n=155). Factor V Leiden vs. Women without Factor V Leiden was evaluated on Frequency of women with fetal loss (spontaneous abortion) (p=0.1). Factor V Leiden was not associated with an increased risk of fetal loss, occurring in 10% of women with the mutation compared to 9% of women without it (p=0.1).
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