Why the study?
Do diazepam and midazolam cause direct myocardial depression in cultured rat ventricular myocytes?
Population
Cultured ventricular myocytes of neonatal rats
Design
Preclinical
Follow-up
4 minutes
Authors
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Indicates possible direct cardiodepressant actions of benzodiazepines in isolated myocytes; leaves open translation to clinical effects.
Do diazepam and midazolam cause direct myocardial depression in cultured rat ventricular myocytes?
Diazepam and midazolam exert direct myocardial depressant effects at the cellular level, primarily mediated by inhibition of the sarcolemmal L-type Ca2+ channel.
Nakae et al. (1997) studied this question.
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