What question did this study set out to answer?

To determine whether elevated post-exercise serum enzyme levels in marathon runners reflect cardiac injury or skeletal muscle damage.

August 1, 1987European Journal of Clinical Investigation

Comparison of serum cardiac specific troponin‐I with creatine kinase, creatine kinase‐MB isoenzyme, tropomyosin, myoglobin and C‐reactive protein release in marathon runners: cardiac or skeletal muscle trauma?

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Why the study?

Does severe muscle exercise (marathon running) cause cardiac muscle damage as measured by cardiac-specific troponin-I in marathon runners?

Key Points

To determine whether elevated post-exercise serum enzyme levels in marathon runners reflect cardiac injury or skeletal muscle damage.
Assessed pre- and post-race serum biomarker levels in 11 marathon runners (N=11) across 63 total samples collected between 1 h and 128 h post-race.
Measured concentrations of cardiac-specific myofibrillar troponin-I, total creatine kinase, creatine kinase-MB isoenzyme, myoglobin, myofibrillar tropomyosin, and C-reactive protein.
Total creatine kinase, creatine kinase-MB isoenzyme, tropomyosin, and myoglobin were significantly elevated above pre-race levels in all runners between 1 h and 128 h post-race.
Neither cardiac troponin-I nor C-reactive protein was elevated post-race, and no samples exceeded twice the upper normal limit for either marker.
Nine of sixty-three samples met conventional criteria for cardiac damage based on CK and CK-MB levels across six runners, but correlation analysis identified skeletal muscle as the sole source of elevated proteins.

Structured PICO

Does severe muscle exercise (marathon running) cause cardiac muscle damage as measured by cardiac-specific troponin-I in marathon runners?

Population

11 marathon runners

Intervention

Severe muscle exercise (marathon running)

Comparator

Pre-race baseline levels

Outcome

Pre- and post-race serum levels of cardiac-specific myofibrillar troponin-I, total creatine kinase, creatine kinase-MB isoenzyme, myoglobin, myofibrillar tropomyosin, and C-reactive proteinsurrogate

Cardiac-specific troponin-I is not elevated after marathon running, demonstrating that post-race elevations in CK and CK-MB are due to skeletal rather than cardiac muscle trauma.

Discussion

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Implication

Post-marathon CK/CK-MB elevations reflect skeletal damage; supports troponin-I specificity but leaves open relevance to high-sensitivity assays.

Cite This Study

Cummins et al. (1987) studied this question.

synapsesocial.com/papers/6a7172d622b3175134db626a https://doi.org/10.1111/j.1365-2362.1987.tb02194.x

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Implication

Post-marathon CK/CK-MB elevations reflect skeletal damage; supports troponin-I specificity but leaves open relevance to high-sensitivity assays.

Comparison of serum cardiac specific troponin‐I with creatine kinase, creatine kinase‐MB isoenzyme, tropomyosin, myoglobin and C‐reactive protein release in marathon runners: cardiac or skeletal muscle trauma?

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Comparison of serum cardiac specific troponin‐I with creatine kinase, creatine kinase‐MB isoenzyme, tropomyosin, myoglobin and C‐reactive protein release in marathon runners: cardiac or skeletal muscle trauma?

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider