Why the study?
Is systemic lupus erythematosus associated with increased pulse wave velocity compared to controls?
Is systemic lupus erythematosus associated with increased pulse wave velocity compared to controls?
Patients with systemic lupus erythematosus have significantly increased arterial stiffness as measured by pulse wave velocity, which is associated with BMI and disease duration.
SLE patients show higher PWV; confirms arterial stiffness association but leaves open impact on risk stratification or therapy.
Systemic lupus erythematosus (SLE) is associated with increased cardiovascular risk. This study aims to derive a more precise estimation on pulse wave velocity (PWV) level in patients with SLE and related factors. A literature search was performed using PubMed, EMBASE, and The Cochrane Library databases, studies published up to February 28, 2017, in English. Pooled standardized mean difference (SMD) with 95% confidence interval (CI) was calculated by fixed-effect or random-effect model analysis. Heterogeneity test was performed by the Q statistic and quantified using I 2 ; publication bias was evaluated using a funnel plot and Egger’s linear regression test. Of 156 studies found, 27 met eligibility criteria, and 14 studies were finally included in the meta-analysis. Meta-analysis revealed that the SLE group had significantly higher PWV levels than the control group; SMD = 0.56 and 95% CI (0.30-0.82). Subgroup analyses showed that body mass index (BMI), sample size, and disease duration were associated with PWV in patients with SLE. Overall, our study suggests that patients with SLE have a higher PWV level, and it is associated with BMI, sample size, and disease duration.
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Wang et al. (2017) studied this question.
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