November 23, 2002Pain Practice

Epidural Calcitonin: Does it Provide Better Postoperative Analgesia? An Analysis of the Haemodynamic, Endocrine, and Nociceptive Responses of Salmon Calcitonin and Opioids in Epidural Anesthesia for Hip Arthroplasty Surgery

View Full Paper

Ask AI

Bookmark

Why the study?

Does epidural salmon calcitonin provide better postoperative analgesia and endocrine stress response compared to epidural fentanyl in patients undergoing hip arthroplasty?

Population

53 ASA I-II patients scheduled for total hip arthroplasty under epidural anaesthesia. Exclusions: history of…

Comparison

Epidural salmon calcitonin 100IU combined with… vs Epidural bupivacaine 0.5% + fentanyl 100 + NaCl…

Design

RCT, Randomly allocated into 3 groups

Follow-up

2 hours postoperatively

Authors

ZGZoi GabopoulouKAT General Hospital of Attica AVAthina VadaloucaDemocritus University of Thrace KVK. Velmachou

Discussion

Member takes

Implication

Supports epidural calcitonin as opioid alternative after hip arthroplasty; extends RCT evidence for non-opioid adjuvants in regional analgesia.

Structured PICO

Does epidural salmon calcitonin provide better postoperative analgesia and endocrine stress response compared to epidural fentanyl in patients undergoing hip arthroplasty?

Population

53 ASA I-II patients scheduled for total hip arthroplasty under epidural anaesthesia. Exclusions: history of pituitary gland dysfunction, diabetes mellitus, obesity, contraindications to epidural block, allergy to calcitonin.

Intervention

Epidural salmon calcitonin 100IU (1 mL) combined with either bupivacaine 0.5% (5 mL) and NaCl 0.9% (4 mL) or just NaCl 0.9% (9 mL) administered postoperatively.

Comparator

Epidural bupivacaine 0.5% (5 mL) + fentanyl 100 (2 mL) + NaCl 0.9% (3 mL) administered postoperatively.

Outcome

Analgesic effects on postoperative pain, haemodynamic parameters, and endocrine responses (glucose, cortisol, growth hormone, prolactin) at 1 and 2 hours postoperatively.patient reported

Epidural salmon calcitonin combined with a local anaesthetic is a suitable alternative to opioids for acute postoperative pain management, offering similar analgesia and stable hemodynamics.

Cite This Study

Gabopoulou et al. (2002) studied this question.

synapsesocial.com/papers/6a717be235aa2c282ce2c46c https://doi.org/10.1046/j.1533-2500.2002.02042.x

View Full Paper

Ask AI

Bookmark

Implication

Supports epidural calcitonin as opioid alternative after hip arthroplasty; extends RCT evidence for non-opioid adjuvants in regional analgesia.

Epidural Calcitonin: Does it Provide Better Postoperative Analgesia? An Analysis of the Haemodynamic, Endocrine, and Nociceptive Responses of Salmon Calcitonin and Opioids in Epidural Anesthesia for Hip Arthroplasty Surgery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Epidural Calcitonin: Does it Provide Better Postoperative Analgesia? An Analysis of the Haemodynamic, Endocrine, and Nociceptive Responses of Salmon Calcitonin and Opioids in Epidural Anesthesia for Hip Arthroplasty Surgery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider