Why the study?
Does epidural anaesthesia or three-in-one block reduce postoperative pain and endocrine stress response compared to intravenous patient-controlled analgesia in patients undergoing total knee arthroplasty?
Population
63 patients (3 groups of 21 each) undergoing total knee arthroplasty
Comparison
Epidural catheter analgesia or three-in-one block vs Intravenous patient-controlled analgesia
Design
RCT, randomized
Follow-up
up to 180 min after the start of pain therapy
Authors
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Epidural anaesthesia attenuates sympathoadrenergic response more than alternatives despite equivalent analgesia after TKA; confirms its distinct perioperative stress-modulating effect.
Does epidural anaesthesia or three-in-one block reduce postoperative pain and endocrine stress response compared to intravenous patient-controlled analgesia in patients undergoing total knee arthroplasty?
While all three pain management methods provided sufficient analgesia, epidural anaesthesia was superior in reducing the sympathoadrenergic stress response.
Adams et al. (2002) studied this question.
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