Key result
Multimodal analgesia improves postoperative pain management and controls the perioperative stress response.
Why the study?
Pain initiates the perioperative stress response while stress potentiates pain intensity, making their bidirectional interaction and multimodal analgesia strategies critical to investigate.
Design
Review
Authors
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Multimodal analgesia may aid perioperative stress balance; extends mechanistic synthesis but leaves open need for RCTs before practice change.
Multimodal analgesia strategies can enhance postoperative recovery by simultaneously reducing pain and modulating the perioperative stress response.
Li et al. (2025) conducted a review in Perioperative pain and stress. Multimodal analgesia was evaluated. Multimodal analgesia strategies, including regional blocks, NSAIDs, lidocaine, and NMDAR antagonists, can effectively control the perioperative stress response and improve postoperative pain management.
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