Key result
Epidural bupivacaine resulted in significantly lower serum cortisol levels 24 hours after elective abdominal surgery compared to intravenous dexmedetomidine (P=0.029).
Why the study?
Does intravenous dexmedetomidine compared to epidural bupivacaine improve suppression of perioperative stress response in adult patients undergoing elective abdominal surgery?
Population
50 adult ASA I/II patients undergoing elective abdominal surgery. Exclusions: laparoscopic surgery…
Comparison
Intravenous dexmedetomidine in addition to… vs Epidural bupivacaine in addition to balanced…
Design
RCT, randomized
Follow-up
24 hours postoperatively
Authors
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Supports epidural bupivacaine over IV dexmedetomidine for perioperative stress attenuation in abdominal surgery; extends RCT comparisons of regional versus systemic adjuncts.
RCT (n=50)
randomized
Does intravenous dexmedetomidine compared to epidural bupivacaine improve suppression of perioperative stress response in adult patients undergoing elective abdominal surgery?
p-value: p=0.029
Epidural bupivacaine is more effective than intravenous dexmedetomidine for suppressing the neuroendocrine and metabolic stress response to elective abdominal surgery, though dexmedetomidine provides better hemodynamic stability.
Salhotra et al. (2022) conducted an RCT in Elective abdominal surgery (n=50). Dexmedetomidine vs. Epidural bupivacaine was evaluated on Serum cortisol levels 24 h after surgery (p=0.029). Epidural bupivacaine resulted in significantly lower serum cortisol levels 24 hours after elective abdominal surgery compared to intravenous dexmedetomidine (P=0.029).