Why the study?
Anticoagulation is sometimes withheld from elderly patients with AF due to concerns about frailty, but whether frailty increases bleeding events remains unknown.
Does a high frailty index increase the risk of major bleeding events in patients with non-valvular atrial fibrillation receiving anticoagulation therapy?
Population
120 consecutive non-valvular AF patients admitted with AF symptoms or congestive heart failure
Comparison
CHS frailty index score or risk categories
Design
Retrospective analysis
Follow-up
Median 518 days
Authors
Loading...
Frailty may warrant bleeding risk caution during anticoagulation in AF; leaves open whether frailty assessment should guide therapy.
Does a high frailty index increase the risk of major bleeding events in patients with non-valvular atrial fibrillation receiving anticoagulation therapy?
Frailty, defined by a CHS frailty index ≥2, is significantly associated with an increased risk of major bleeding events in patients with non-valvular atrial fibrillation receiving anticoagulation.
Ohta et al. (2021) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: