Why the study?
Atrial fibrillation and frailty are common and increasing, but the prevalence of frailty and the ability of a frailty index to predict unplanned hospitalizations, stroke, bleeding, and death in AF patients required investigation.
Does frailty predict unplanned hospitalization, stroke, bleeding, and death in patients with atrial fibrillation?
Population
2369 patients with known AF in Switzerland
Comparison
Frail and pre-frail patients vs non-frail patients
Design
Prospective cohort study
Key result
Frailty and pre-frailty in patients with atrial fibrillation were associated with a higher risk of unplanned hospitalizations (aHR 3.59, 95% CI 2.78-4.63 and aHR 1.82, 95% CI 1.49-2.22, respectively).
Authors
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Frailty assessment may aid AF risk stratification; leaves open whether interventions modify outcomes.
Cohort (n=2,369)
Does frailty predict unplanned hospitalization, stroke, bleeding, and death in patients with atrial fibrillation?
Hazard Ratio: 3.59 (95% CI 2.78–4.63)
p-value: p=< 0.001
Over two-thirds of patients with atrial fibrillation are pre-frail or frail, which strongly predicts unplanned hospitalizations, mortality, bleeding, and stroke.
Gugganig et al. (2020) conducted a cohort in Atrial fibrillation (n=2,369). Frailty vs. Non-frail was evaluated on unplanned hospitalization (aHR 3.59, 95% CI 2.78-4.63, p=< 0.001). Frailty and pre-frailty in patients with atrial fibrillation were associated with a higher risk of unplanned hospitalizations (aHR 3.59, 95% CI 2.78-4.63 and aHR 1.82, 95% CI 1.49-2.22, respectively).
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