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February 6, 2021European Journal of Clinical Investigation

After multivariate adjustment, FRAIL score [HR 1.41, (95% CI 1.02-1.97); P = .040] and Charlson index [HR 1.32, (95% CI 1.09-1.59); P = .003] were significantly associated with mortality, whereas AF status was not independently related with adverse events.

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Why the study?

Information on the prognostic role of frailty and atrial fibrillation in elderly patients with acute coronary syndrome was scarce.

Does frailty and atrial fibrillation status predict adverse events in elderly patients with acute coronary syndrome?

Population

531 unselected ACS patients above 80 years old

Comparison

Frailty and AF status categories

Design

Prospective multicentre registry

Follow-up

6-month follow-up

Authors

MEMaría Asunción Esteve‐PastorEME. MartínOAOriol Alegre

Discussion

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Member takes

Overview

Frailty may refine prognosis in elderly ACS beyond AF status; leaves open whether it should alter management.

Structured PICO

Does frailty and atrial fibrillation status predict adverse events in elderly patients with acute coronary syndrome?

P
Population
531 unselected patients with acute coronary syndrome (ACS) aged >80 years, mean age 84.4 (SD = 3.6) years, 60.6% male.
I
Intervention
Frailty and/or atrial fibrillation (AF)
C
Comparator
Non-frail and sinus rhythm (SR)
O
Outcome
Adverse events (all-cause mortality, readmissions, and their composite) at 6-month follow-uphard clinical

In elderly patients with acute coronary syndrome, frailty and overall comorbidity burden are independent predictors of adverse events at 6 months, whereas atrial fibrillation status is not.

Cite This Study

Esteve‐Pastor et al. (2021) studied this question.

synapsesocial.com/papers/6a8a84bee0083a7c2c437c4fhttps://doi.org/10.1111/eci.13505
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epidemiology and impact of frailty in patients with atrial fibrillation in Europe2022 · 72 citations
  2. 2Frailty to predict unplanned hospitalization, stroke, bleeding, and death in atrial fibrillation2020 · 58 citations
  3. 3Impact of Frailty on Healthcare Outcomes after Cardioembolic Ischaemic Stroke Due to Atrial Fibrillation2024 · 1 citations
  4. 4The hospital frailty risk score effectively predicts adverse outcomes in patients with atrial fibrillation in the intensive care unit2024 · 2 citations
  5. 5Is frailty associated with short-term outcomes for elderly patients with acute coronary syndrome?2015 · 62 citations