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November 1, 2015Open Access

Is frailty associated with short-term outcomes for elderly patients with acute coronary syndrome?

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Key result

Frailty was independently associated with increased risk of all-cause mortality (HR 5.393 per 1-category increment) and unscheduled return visits in elderly patients with acute coronary syndrome.

Why the study?

Does frailty increase the risk of short-term adverse outcomes in elderly patients with acute coronary syndrome?

Population

352 patients aged ≥ 65 years with diagnosed acute coronary syndrome from a single center in China. Median…

Comparison

Frailty vs Non-frail

Design

Cohort

Follow-up

median 120 days

Authors

LKLin KangChinese Academy of Medical Sciences & Peking Union Medical CollegeYZYuanqiang ZhangUniversity of California, RiversideWZWen-ling ZhuWater and Power Development Authority

Discussion

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Implication

Supports frailty evaluation in elderly ACS risk assessment; leaves open whether modifying frailty alters outcomes.

Study Design

Type

Cohort (n=352)

Multicenter

No

Structured PICO

Does frailty increase the risk of short-term adverse outcomes in elderly patients with acute coronary syndrome?

P
Population
352 elderly patients aged 65 years and older with acute coronary syndrome, followed for a median of 120 days.
E
Exposure
Frailty (defined as Clinical Frailty Scale score 5-7)
C
Comparator
Non-frail (defined as Clinical Frailty Scale score 1-4)
O
Outcome
Composite of all-cause mortality and unscheduled returned visit at median 120 days follow-upcomposite

Main Result

Hazard Ratio: 5.393 (95% CI 1.477–19.692)

p-value: p=0.011

Frailty is a strong, independent predictor of short-term all-cause mortality and unscheduled return visits in elderly patients with acute coronary syndrome.

Limitations

  • Single-center study design
  • Relatively small sample size
  • Short follow-up period (median 120 days)
  • Observational design cannot establish causality

Cite This Study

Kang et al. (2015) conducted a cohort in Acute coronary syndrome (n=352). Frailty (Clinical Frailty Scale) vs. Non-frail was evaluated on All-cause mortality (HR 5.393, 95% CI 1.477-19.692, p=0.011). Frailty was independently associated with increased risk of all-cause mortality (HR 5.393 per 1-category increment) and unscheduled return visits in elderly patients with acute coronary syndrome.

synapsesocial.com/papers/6a959fbc1fd62c0cf5676d57https://doi.org/10.11909/j.issn.1671-5411.2015.06.010
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Also Consider

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