Key result
Frailty was associated with a significantly higher adjusted risk of all-cause mortality (HR 2.65) compared to robust patients among elderly individuals with acute coronary syndrome.
Why the study?
Frailty is common and associated with poorer outcomes in the elderly, but its prognostic value in ACS required clarification.
Does frailty predict mortality and adverse events in elderly patients with acute coronary syndrome?
Population
Elderly patients with ACS
Comparison
Frail patients vs non-frail patients
Design
Systematic review and meta-analysis
Authors
Loading...
May aid frailty screening for prognostication in elderly ACS; confirms elevated mortality and adverse event risks across studies.
Meta-Analysis (n=8,554)
Yes
Does frailty predict mortality and adverse events in elderly patients with acute coronary syndrome?
Effect estimate: HR 2.65 (95% CI 1.81-3.89)
Frailty provides significant prognostic value for mortality, cardiovascular events, major bleeding, and readmissions in elderly patients with acute coronary syndrome.
Dou et al. (2019) conducted a meta-analysis in Acute coronary syndrome (ACS) (n=8,554). Frailty vs. Normal/robust group was evaluated on Adjusted all-cause mortality (HR 2.65, 95% CI 1.81-3.89). Frailty was associated with a significantly higher adjusted risk of all-cause mortality (HR 2.65) compared to robust patients among elderly individuals with acute coronary syndrome.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: