Assembly and Influencing Factors of IMPDH2 Cytoophidia

Cytoophidium is a rod or ring structure composed of metabolically related enzymes. Inosine-5'-monophosphate dehydrogenase ( IMPDH ) is a rate-limiting enzyme that catalyzes the de novo biosynthetic pathway of guanine nucleotides and plays a very important role in cell proliferation, cell differentiation, maintenance of body balance and metabolism. The study found that  IMPDH2  gene can be assembled into a special structure of protein polymer fibers, named  IMPDH2  cytoophidia, the structure is a natural biological phenomenon related to purine metabolism, as a fine-tuning protein adapted to the intracellular and extracellular environment changes. This article reviews the structure of  IMPDH2  and  IMPDH2  cytoophidia, the assembly process and the influencing factors of  IMPDH2  cytoophidia.