With the deepening of neuroscientific research, traditional research methods have become difficult to meet the comprehensive analysis of the complexity and heterogeneity of the nervous system. The rise of single-cell omics technologies has brought new opportunities to neuroscientific research. This review summarizes the heterogeneity of nerve cells and the basic principles, advantages, and limitations of single-cell omics technologies. Through specific cases, it delves into the application of single-cell omics technologies in the study of neurons and synapses, the analysis of the pathogenesis of neurodegenerative diseases, as well as neural regeneration and repair research, and analyzes their contributions to neuroscience. In addition, this review also looks forward to the future development direction of single-cell omics technologies in neuroscientific research and discusses the current and future technical and ethical challenges and their solutions. This review aims to comprehensively sort out and evaluate the application of single-cell omics technologies in neuroscientific research, hoping to provide useful references and insights for researchers in related fields.
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Jiayao Zhou (2024) studied this question.
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