PMMA Bone Cement: Properties, Applications, and Innovations

Polymethylmethacrylate (PMMA) bone cement has been a fundamental material in orthopedic and dental surgeries for decades, primarily serving to stabilize implants and facilitate bone healing. This review explores the properties, clinical applications, challenges, and recent innovations related to PMMA. The chemical and mechanical properties of PMMA, including its compressive strength and biocompatibility, underscore its utility in procedures such as joint arthroplasties and vertebroplasty. However, limitations such as biomechanical mismatch, thermal damage during polymerization, and susceptibility to infection pose significant challenges. Recent advancements aim to address these issues through the development of antibiotic-loaded formulations, bioactive additives, and smart biomaterials that enhance osseointegration and reduce complications. As research continues to evolve, the future of PMMA bone cement looks promising, with innovations poised to improve patient outcomes and expand its applications in medicine.