What question did this study set out to answer?

To identify clinical, radiological, electrophysiological, and biochemical predictors of short- and long-term outcomes and multiple sclerosis conversion in patients experiencing a first episode of acute myelitis.

June 1, 2010Archives of Neurology

Assessment of Outcome Predictors in First-Episode Acute Myelitis

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To identify clinical, radiological, electrophysiological, and biochemical predictors of short- and long-term outcomes and multiple sclerosis conversion in patients experiencing a first episode of acute myelitis.
Retrospective review of 53 patients with first-episode acute myelitis at a single center followed for a median of 6.2 years.
Assessed clinical status, spinal and brain MRI, somatosensory evoked potentials, and de novo levels of tau, 14-3-3 protein, and cystatin C in archived cerebrospinal fluid.
Conversion to multiple sclerosis occurred in 79% of patients (42/53), predicted by absent sensory levels, preserved sphincter function, abnormal brain MRI, spinal cord lesions spanning fewer than 3 segments, and abnormal somatosensory evoked potentials.
Significant disability at final follow-up occurred in 47% (15/32) with baseline pyramidal dysfunction versus 10% (2/21) without (P = .006), and in 40% (17/43) with relapses versus 0% without (P = .02).
Among 11 patients with relapsing disease, cerebrospinal fluid cystatin C levels correlated significantly with neurological disability at last follow-up (Spearman rho = 0.69; P = .03).

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Implication

Retrospective study uncovers clinical and biomarker predictors of disability in first-episode acute myelitis, highlighting high rates of multiple sclerosis conversion.

Cite This Study

Gajofatto et al. (2010) studied this question.

synapsesocial.com/papers/6a71839035aa2c282ce2c846 https://doi.org/10.1001/archneurol.2010.107

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Implication

Retrospective study uncovers clinical and biomarker predictors of disability in first-episode acute myelitis, highlighting high rates of multiple sclerosis conversion.

Assessment of Outcome Predictors in First-Episode Acute Myelitis

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Discussion

Implication

Cite This Study

Assessment of Outcome Predictors in First-Episode Acute Myelitis

Key Points

Discussion

Implication

Cite This Study

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