Why the study?
Does cromakalim open ATP-sensitive potassium channels in insulin-secreting cells?
Population
Insulin-secreting cell-line RINm5F
Comparison
Cromakalim (80-800 microM), diazoxide, and ATP vs Absence of internal ATP, varying concentrations…
Design
Preclinical
Authors
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Should not change clinical practice; leaves open ATP-dependent KATP modulation in beta cells.
Does cromakalim open ATP-sensitive potassium channels in insulin-secreting cells?
Cromakalim opens ATP-sensitive potassium channels in insulin-secreting cells via a mechanism likely involving protein phosphorylation, requiring the presence of ATP.
Dunne et al. (1990) studied this question.
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