Why the study?
Betatrophin regulates lipid and glucose metabolism, but its association with insulin resistance in women with polycystic ovary disease required assessment.
Is serum betatrophin associated with insulin resistance in women with polycystic ovary disease?
Is serum betatrophin associated with insulin resistance in women with polycystic ovary disease?
Serum betatrophin levels are significantly elevated in women with PCOS and are positively correlated with markers of insulin resistance.
May indicate betatrophin-IR link in PCOS; leaves open causal role and clinical utility.
Background: Betatrophin, a newly identified peptide hormone secreted mainly by liver and adipose tissue, is a member of a family of angiopoietin-like proteins and is implicated in the regulation of lipid and glucose metabolism. Originally, betatrophin was determined to function in lipid metabolism by reducing triglyceride clearance through lipoprotein lipase inhibition. Objective: To assess the association between Betatrophin and insulin resistance in polycystic ovary disease women. Patients and Method: A case control study carried in our hospital, at the period from the 1st of October 2019 to the end of January 2020. One hundred women were enrolled in the current study and divided into 2 groups. Results: S. Betatrophin levels were significantly higher increases in case group (PCOS patients) than that in control group (P<0.001). The correlation analysis between serum Betatrophin and various parameters in table 4 showed that there is a positive correlation between circulating Betatrophin levels with fasting insulin, and HOMA-IR. While negative correlation found with fasting blood glucose. Conclusion: Betatrophin highly significantly increase in PCOS patients, and betatrophin is independently associated with insulin resistance.
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Saeed et al. (2021) studied this question.
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