Key result
Patients with polycystic ovary syndrome had significantly higher circulating betatrophin levels compared to matched controls (772.6 vs. 685.3 pg/ml), particularly those with insulin resistance.
Why the study?
Are circulating betatrophin levels associated with polycystic ovary syndrome and insulin resistance?
Population
162 patients with polycystic ovary syndrome (PCOS) and 156 matched control females
Design
Case-control
Authors
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May support betatrophin as PCOS biomarker in insulin resistance; hypothesis-generating pending prospective validation.
Case-Control (n=318)
Are circulating betatrophin levels associated with polycystic ovary syndrome and insulin resistance?
Absolute Event Rate: 772.6% vs 685.3%
Serum betatrophin levels are significantly elevated in women with PCOS and correlate strongly with insulin resistance, suggesting a potential role as a biomarker.
Qu et al. (2017) conducted a case-control in Polycystic ovary syndrome (PCOS) (n=318). Polycystic ovary syndrome vs. Matched control females was evaluated on Circulating betatrophin levels (pg/ml). Patients with polycystic ovary syndrome had significantly higher circulating betatrophin levels compared to matched controls (772.6 vs. 685.3 pg/ml), particularly those with insulin resistance.
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