Key result
Women with PCOS show elevated serum betatrophin levels linked to age and waist-hip ratio.
Why the study?
Are serum betatrophin levels elevated in women with polycystic ovary syndrome compared to healthy controls?
Case-Control (n=140)
Are serum betatrophin levels elevated in women with polycystic ovary syndrome compared to healthy controls?
Serum betatrophin levels are elevated in women with PCOS and are independently associated with age and waist-hip ratio, but not with insulin resistance.
Elevated betatrophin in PCOS links to adiposity; hypothesis-generating and should not yet change practice or guide management.
OBJECTIVE: To determine serum levels of betatrophin in patients with polycystic ovary syndrome (PCOS) and the influential factors. METHODS: A total of 100 PCOS patients were enrolled randomly as a PCOS group, and 40 age-matched healthy women were recruited as a normal control (NC) group. Primary clinical or biochemical parameters of the subjects were detected. The results were analyzed by SPSS 19.0. RESULTS: Serum betatrophin levels were elevated in the PCOS group compared with the NC group. Serum betatrophin levels were positively correlated with age and Whole Body Insulin Sensitivity Index (WBISI),and negatively correlated with body mass index, fasting insulin(FINS), homeostatic model assessment insulin resistance (HOMA-IR) and homeostatic model assessment β cell function (HOMA-β). Multiple linear stepwise regression analysis showed that age and waist hip ratio (WHR) were independent influential factors for the level of betatrophin. PCOS was more likely to occur in women with higher betatrophin levels. CONCLUSION: Serum betatrophin levels increase in women with PCOS and they are independently associated with age and WHR. There is no significant correlation between betatrophin and insulin resistance or insulin levels.
No takes yet. Share an insight, caveat, or question.
Song et al. (2016) conducted a case-control in Polycystic ovary syndrome (n=140). Polycystic ovary syndrome vs. Healthy women was evaluated on Serum betatrophin levels. Serum betatrophin levels were elevated in women with polycystic ovary syndrome compared to healthy controls and were independently associated with age and waist-hip ratio.