June 6, 2001JAMA
High-Density Lipoprotein Cholesterol and Ischemic Stroke in the Elderly
Why the study?
Do higher HDL-C levels reduce the risk of ischemic stroke in an elderly, racially or ethnically diverse population?
Population
1,444 participants from a multiethnic community in northern Manhattan, NY, comprising 539 cases of first…
Comparison
Higher fasting HDL-C levels vs Lower fasting HDL-C levels (<35 mg/dL)
Design
Case-control
Authors
Discussion
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Member takes
Implication
Supports HDL-C assessment for ischemic stroke risk in diverse elderly; leaves open causality and intervention benefits.
Structured PICO
Do higher HDL-C levels reduce the risk of ischemic stroke in an elderly, racially or ethnically diverse population?
P
Population
1,444 participants from a multiethnic community in northern Manhattan, NY, comprising 539 cases of first ischemic stroke (67% aged >=65 years, 55% women, 53% Hispanic, 28% black, 19% white) and 905 stroke-free community residents matched by age, sex, and race/ethnicity.
I
Intervention
Higher fasting HDL-C levels (≥35 mg/dL, 35-49 mg/dL, and ≥50 mg/dL)
C
Comparator
Lower fasting HDL-C levels (<35 mg/dL)
O
Outcome
First ischemic stroke, including atherosclerotic and nonatherosclerotic ischemic stroke subtypeshard clinical
Higher HDL-C levels are independently associated with a dose-dependent reduction in the risk of ischemic stroke, particularly the atherosclerotic subtype, across diverse racial and ethnic groups.
Cite This Study
Sacco et al. (2001) studied this question.