April 1, 1999AJP Regulatory Integrative and Comparative Physiology

RVLM and raphe differentially regulate sympathetic outflows to splanchnic and brown adipose tissue

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Population

Urethan-chloralose-anesthetized ventilated rats

Comparison

Acute hypothermia and microinjection of… vs Control (baseline levels)

Design

Preclinical

Authors

SMShaun F. MorrisonOregon National Primate Research Center

Discussion

Member takes

Implication

Supports distinct central sympathetic pathways for thermoregulation versus cardiovascular control in rodents; leaves open human translation.

Structured PICO

Population

Urethan-chloralose-anesthetized ventilated rats

Intervention

Acute hypothermia and microinjection of bicuculline into rostral raphe pallidus (RPa); microinjections of bicuculline or muscimol into rostral ventrolateral medulla (RVLM)

Comparator

Control (baseline levels)

Outcome

Responses in sympathetic nerve activity to brown adipose tissue (BAT SNA) and splanchnic (Spl) SNA, and arterial pressure (AP)surrogate

Central pathways regulating sympathetic outflow to tissues involved in thermoregulation (BAT) are distinct from those controlling cardiovascular sympathetic outflow (splanchnic).

Cite This Study

Shaun F. Morrison (1999) studied this question.

synapsesocial.com/papers/6a718bb86c240de38cdc2b67 https://doi.org/10.1152/ajpregu.1999.276.4.r962

View Full Paper

Ask AI

Bookmark

Implication

Supports distinct central sympathetic pathways for thermoregulation versus cardiovascular control in rodents; leaves open human translation.

RVLM and raphe differentially regulate sympathetic outflows to splanchnic and brown adipose tissue

Discussion

Member takes

Implication

Structured PICO

Cite This Study

RVLM and raphe differentially regulate sympathetic outflows to splanchnic and brown adipose tissue

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider