What question did this study set out to answer?

To determine how human C apolipoproteins affect the in vitro hepatic uptake and metabolism of triglyceride emulsions in a rat model.

December 1, 1982Journal of Biological ChemistryOpen Access

The effect of human C apolipoproteins on the in vitro hepatic metabolism of triglyceride emulsions in the rat.

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Authors

SQSteven H. QuarfordtUniversity of North Carolina at Chapel Hill GMGeorge K. MichalopoulosUniversity of Vermont BSBruce D. SchirmerUniversity of Virginia

Discussion

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Implication

In vitro experimental study demonstrates modulation of triglyceride metabolism in rat liver, indicating a key regulatory role for human C apolipoproteins.

Key Points

To determine how human C apolipoproteins affect the in vitro hepatic uptake and metabolism of triglyceride emulsions in a rat model.
Conducted in vitro assays using rat liver tissue preparations exposed to artificial triglyceride emulsions.
Evaluated the specific activity of human C apolipoprotein variants, particularly apolipoprotein C-III containing two sialic acid residues.
Human C apolipoproteins directly interact with triglyceride emulsions to alter their clearance rate by hepatic tissues in vitro.
Variations in apolipoprotein structure, including specific sialic acid content, regulate how efficiently liver cells process circulating fat particles.

Cite This Study

Quarfordt et al. (1982) studied this question.

synapsesocial.com/papers/6a718c6126a7f98052ddda8b https://doi.org/10.1016/s0021-9258(18)33329-5

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December 1, 1982Journal of Biological ChemistryOpen Access

The effect of human C apolipoproteins on the in vitro hepatic metabolism of triglyceride emulsions in the rat.

View Full Paper

Ask AI

Bookmark

Authors

SQSteven H. QuarfordtUniversity of North Carolina at Chapel Hill GMGeorge K. MichalopoulosUniversity of Vermont BSBruce D. SchirmerUniversity of Virginia

Discussion

Member takes

Implication

In vitro experimental study demonstrates modulation of triglyceride metabolism in rat liver, indicating a key regulatory role for human C apolipoproteins.

Key Points

To determine how human C apolipoproteins affect the in vitro hepatic uptake and metabolism of triglyceride emulsions in a rat model.
Conducted in vitro assays using rat liver tissue preparations exposed to artificial triglyceride emulsions.
Evaluated the specific activity of human C apolipoprotein variants, particularly apolipoprotein C-III containing two sialic acid residues.
Human C apolipoproteins directly interact with triglyceride emulsions to alter their clearance rate by hepatic tissues in vitro.
Variations in apolipoprotein structure, including specific sialic acid content, regulate how efficiently liver cells process circulating fat particles.

Cite This Study

Quarfordt et al. (1982) studied this question.

synapsesocial.com/papers/6a718c6126a7f98052ddda8b https://doi.org/10.1016/s0021-9258(18)33329-5

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