Extraadrenal steroid 21-hydroxylation is not mediated by P450c21.

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1Extraadrenal Formation of a Mineralocorticosteroid: Deoxycorticosterone and Deoxycorticosterone Sulfate Biosynthesis and Metabolism*1982 · 82 citations
2. 2Developmental Expression of Genes for the Stereoidogenic Enzymes P450scc (20,22-Desmolase), P450cl7 (17αHydroxylase/17,20-Lyase), and P450c21 (21-Hydroxylase) in the Human Fetus*1986 · 186 citations
3. 3Extraadrenal Steroid 21-Hydroxylase Activity in a Woman with Congenital Adrenal Hyperplasia due to Steroid 21-Hydroxylase Deficiency*1983 · 36 citations
4. 4A Method for Isolation of Intact, Translationally Active Ribonucleic Acid1983 · 1,469 citations
5. 5The Role of Renin and Angiotensin in Salt-Losing, 21- Hydroxylase-Deficient Congenital Adrenal Hyperplasia*1979 · 51 citations