Why the study?
Does AT1A receptor knockout or AT2 receptor blockade alter blood pressure in a 2K1C mouse model of hypertension?
Population
AT ANG II receptor knockout and wild-type mice undergoing clipping of the right renal artery
Comparison
AT2 receptor blockade with PD 123319 and acute… vs Wild-type mice, unclipped mice, and baseline…
Design
Preclinical
Follow-up
26 days
Authors
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AT1A receptors mediate 2K1C hypertension in this model; leaves open translation to human renovascular disease.
Does AT1A receptor knockout or AT2 receptor blockade alter blood pressure in a 2K1C mouse model of hypertension?
AT1A receptors are essential for mediating 2K1C hypertension in mice, and augmented NO production serves as a counteracting system in this model.
Červenka et al. (2002) studied this question.
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