Why the study?
Does AT1A receptor knockout or AT2 receptor activation alter blood pressure development in 2K1C hypertensive mice?
Population
Wild-type and AT1A receptor knockout mice undergoing two-kidney, one-clip Goldblatt hypertension modeling
Comparison
Infusion with selective AT2 receptor agonist… vs Saline vehicle infusion
Design
Preclinical
Authors
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Should not change practice in renovascular hypertension; hypothesis-generating for AT1A targeting while leaving AT2 agonism effects open.
Does AT1A receptor knockout or AT2 receptor activation alter blood pressure development in 2K1C hypertensive mice?
AT1A receptors play a critical role in the development of 2K1C hypertension, while AT2 receptor activation does not antagonize this effect.
Červenka et al. (2008) studied this question.
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