Why the study?
Visual assessment routinely underestimates postpartum hemorrhage blood loss beyond the point of pharmaceutical intervention, highlighting the need for quantitative monitoring of compensatory peripheral vasoconstriction as an early alert.
Does a wearable optical device monitoring peripheral perfusion via LSFI accurately detect hemorrhage-induced peripheral vasoconstriction compared to vital sign metrics in a swine model of hemorrhage?
Does a wearable optical device monitoring peripheral perfusion via LSFI accurately detect hemorrhage-induced peripheral vasoconstriction compared to vital sign metrics in a swine model of hemorrhage?
A novel wearable optical device using laser speckle flow index accurately detects hemorrhage-induced peripheral vasoconstriction in a swine model, outperforming standard vital sign metrics.
May enable earlier PPH detection via peripheral vasoconstriction monitoring in low-resource settings; leaves open translation from animal data to clinical practice.
Postpartum hemorrhage (PPH) is the leading and most preventable cause of maternal mortality, particularly in low-resource settings. PPH is currently diagnosed through visual estimation of blood loss or monitoring of vital signs. Visual assessment routinely underestimates blood loss beyond the point of pharmaceutical intervention. Quantitative monitoring of hemorrhage-induced compensatory processes, such as the constriction of peripheral vessels, may provide an early alert for PPH. To this end, we developed a low-cost, wearable optical device that continuously monitors peripheral perfusion via laser speckle flow index (LSFI) to detect hemorrhage-induced peripheral vasoconstriction. The measured LSFI signal produced a linear response in phantom models and a strong correlation coefficient with blood loss averaged across subjects (>0.9) in a large animal model, with superior performance to vital sign metrics.
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Bonetta-Misteli et al. (2023) studied this question.
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