Why the study?
Does the required effect-site concentration of remifentanil to attenuate QTc interval prolongation following intubation differ between hypertensive and normotensive female patients?
Population
44 female patients aged ≥ 50 years, comprising 22 normotensive and 22 hypertensive patients.
Comparison
Remifentanil and propofol administered via… vs Normotensive female patients.
Design
Other
Follow-up
Immediate (following intubation)
Authors
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May warrant higher remifentanil dosing in hypertensive patients for intubation; leaves optimal Ce open for randomized confirmation.
Does the required effect-site concentration of remifentanil to attenuate QTc interval prolongation following intubation differ between hypertensive and normotensive female patients?
Hypertensive female patients require a significantly higher effect-site concentration of remifentanil compared to normotensive patients to prevent significant QTc interval prolongation during tracheal intubation.
Kim et al. (2015) studied this question.
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