To Evaluate the Efficacy of Priyalbeejadi Lepa & Aamrabeeja Haritaki Lepa in the Management of Darunaka- A Random, Open Labelled Controlled Study

Background: Darunaka is a common scalp disorder. Priyalbeejadi Lepa was assessed for its role in managing Darunaka. Objective: The study was planned to evaluate the efficacy of Priyalbeejadi Lepa in the management of Darunaka. Methods: The study included forty patients of both sexes, aged 16 to 40, who met Darunaka's diagnostic criteria and were seen in the institute's outpatient department. They were split up at random, with Aamrabeeja Haritaki Lepa administered on alternate days for 30 days to the Controlled Group and Priyalbeejadi Lepa to the Interventional Group. Twakasphutana, Kandu, Keshachyuti, Rookshata, and Adherent Scalp Flaking Score (ASFS) were evaluated. On days 15, 30, and 45, clinical evaluations were conducted. Effect sizes were computed using paired t-tests for within-group comparisons and independent t-tests for between-group comparisons. Results: Following treatment, all clinical metrics significantly improved for both groups (p < 0.01). Twakasphutana demonstrated a statistically significant advantage over the control group (p = 0.044, Cohen's d = 0.66), however the Interventional Group consistently showed larger decreases in mean scores across parameters. Other measures had small to medium effect sizes that favored the Interventional Group and showed gains that were clinically significant. Conclusion: With notable improvements in scalp flaking, itching, and related clinical symptoms, Priyalbeejadi Lepa is a successful intervention for Darunaka. When compared to Aamrabeeja Haritaki Lepa, it had better therapeutic results, indicating its potential as a preferred therapy option.