Highlights inappropriate sinus tachycardia as a potential late cardiac effect in childhood cancer survivors treated with anthracyclines and total body irradiation.
May signal late inappropriate sinus tachycardia in anthracycline/TBI survivors; single case leaves open prevalence and need for prospective confirmation.
SUMMARY: Survivors of childhood cancer and hematopoietic stem cell transplantation are subject to a range of cardiac late effects including conduction abnormalities. We present, the case of a 12-year-old girl diagnosed with inappropriate sinus tachycardia after a history of multiply relapsed acute lymphoblastic leukemia and an exposure history including anthracycline-based chemotherapy followed by the total body irradiation in the context of a hematopoietic stem cell transplant. The clinical importance of this late cardiac effect along with the potential options for therapy is discussed.
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Buchbinder et al. (2009) studied this question.
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