Chronic Staphylococcal enterotoxin B and lipopolysaccharide induce a bimodal pattern of hepatic dysfunction and injury*

David W. A. Beno; Michael R. Uhing; Masakatsu Gotō; Yong Chen; Vanida A. Jiyamapa‐Serna; Robert E. Kimura

doi:10.1097/01.ccm.0000060004.85054.f2

April 1, 2003Critical Care Medicine

Chronic Staphylococcal enterotoxin B and lipopolysaccharide induce a bimodal pattern of hepatic dysfunction and injury*

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Key Points

To determine the effects of chronic concurrent exposure to lipopolysaccharide and Staphylococcal enterotoxin B on hepatic injury and function.
Prospective controlled trial conducted in male Sprague-Dawley rats (325–350 g) surgically fitted with chronic vascular and bile catheters.
Rats received daily treatments for 10 days with saline, Staphylococcal enterotoxin B alone (50 µg/kg), lipopolysaccharide alone (1000 µg/kg), or combined regimens (100 or 1000 µg/kg lipopolysaccharide with 50 µg/kg Staphylococcal enterotoxin B).
Hepatic injury and function were evaluated via serum and biliary markers at baseline, 6 hours, and days 1, 2, 3, 7, and 10, followed by histological liver analysis at day 10.
Combined toxin exposure significantly reduced bile flow, biliary indocyanine green excretion, and bile acid flux at 6 hours to 2 days and again at 10 days, accompanied by parallel bimodal spikes in serum and biliary gamma-glutamyltransferase and serum bile acids.
Rats treated with either lipopolysaccharide or Staphylococcal enterotoxin B alone developed tolerance and did not exhibit the late-phase hepatic dysfunction.
Histologic evaluation at 10 days revealed periportal inflammation and fibrosis exclusively in animals receiving both bacterial toxins.

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Implication

Prospective controlled trial demonstrates bimodal hepatic injury from combined bacterial toxins in rats, indicating dual-toxin exposure drives late liver dysfunction in sepsis.

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Beno et al. (2003) studied this question.

synapsesocial.com/papers/6a7199b878a11c550e0ba2c2 https://doi.org/10.1097/01.ccm.0000060004.85054.f2

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Chronic Staphylococcal enterotoxin B and lipopolysaccharide induce a bimodal pattern of hepatic dysfunction and injury*

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Chronic Staphylococcal enterotoxin B and lipopolysaccharide induce a bimodal pattern of hepatic dysfunction and injury*

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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