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The aim is to investigate the effects of bacterial endotoxin injection on lipid levels and liver health in rabbits.

October 1, 1964Journal of Lipid ResearchOpen Access

Hyperlipidemia, fatty liver, and bromsulfo-phthalein retention in rabbits injected intravenously with bacterial endotoxins

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The aim is to investigate the effects of bacterial endotoxin injection on lipid levels and liver health in rabbits.
Intravenous injection of endotoxins from Serratia marcescens and E. coli into rabbits.
Measurement of plasma free fatty acids, triglycerides, cholesterol, and phospholipid levels.
Assessment of bromsulfophthalein excretion and presence of fatty liver.
Average plasma triglycerides increased 4- to 9-fold and serum cholesterol and phospholipids rose 2- to 3-fold after injection.
Fatty liver was found in 25% of rabbits given two doses of Shear's polysaccharide and in all given E. coli endotoxin.
A correlation was observed between elevated triglyceride levels and increased mortality rates.

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Randomized trial examines lipid changes and liver effects in rabbits exposed to bacterial endotoxins, indicating significant health risks.

Hirsch et al. (1964) studied this question.

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Randomized trial examines lipid changes and liver effects in rabbits exposed to bacterial endotoxins, indicating significant health risks.