What question did this study set out to answer?

To determine whether the variable effects of interleukin-6 on human neutrophil apoptosis depend on cell concentration in culture.

November 1, 1995Journal of Leukocyte Biology

Interleukin-6 suppression of neutrophil apoptosis is neutrophil concentration dependent

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To determine whether the variable effects of interleukin-6 on human neutrophil apoptosis depend on cell concentration in culture.
Isolated polymorphonuclear leukocytes from healthy human donors.
Cultured cells at concentrations ranging from 1 to 20 × 10⁶ cells/mL and incubated them with interleukin-6 doses from 1 to 100 ng/mL.
Interleukin-6 exposure exerted no inhibitory effect on apoptosis in neutrophils cultured at low densities (1–5 × 10⁶ cells/mL).
Interleukin-6 significantly inhibited apoptosis in neutrophils cultured at higher densities (10–20 × 10⁶ cells/mL) relative to untreated controls at identical concentrations.

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Implication

In vitro study reveals interleukin-6 suppresses neutrophil apoptosis only at high cell densities in human leukocytes, highlighting the influence of cell concentration on inflammatory signaling.

Cite This Study

Biffl et al. (1995) studied this question.

synapsesocial.com/papers/6a719a23b5c1fe5ca9dfde0f https://doi.org/10.1002/jlb.58.5.582

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Implication

In vitro study reveals interleukin-6 suppresses neutrophil apoptosis only at high cell densities in human leukocytes, highlighting the influence of cell concentration on inflammatory signaling.

Interleukin-6 suppression of neutrophil apoptosis is neutrophil concentration dependent

Key Points

Discussion

Implication

Cite This Study

Interleukin-6 suppression of neutrophil apoptosis is neutrophil concentration dependent

Key Points

Discussion

Implication

Cite This Study

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