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April 23, 2010PLoS ONEOpen Access

The psychophysical threshold of pain triggered by Adelta-fibers was always higher (2.5-3 degrees C) than that triggered by C-fibers, with mean conduction velocities of 13 and 0.8 m/s, respectively.

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Population

Human subjects (sample size not stated)

Comparison

CO2 laser beam thermal stimulation vs Warmth detection

Design

Other

Authors

LPLéon PlaghkiCDCéline DecruynaerePDPaul Van Dooren

Discussion

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Overview

Offers experimental support for dual-level nociceptive detection; leaves open translation to clinical pain assessment or management.

Structured PICO

P
Population
Human subjects (sample size not stated)
I
Intervention
CO2 laser beam thermal stimulation
C
Comparator
Warmth detection (sensation of warmth elicited by thermoreceptors)
O
Outcome
Thermal thresholds and latencies of pain elicited by Adelta- and C-fiberssurrogate

This experimental approach demonstrates that pain nociception acts as a double level alarm system based on level detectors, whereas warmth detection is based on difference detectors.

Cite This Study

Plaghki et al. (2010) studied this question.

synapsesocial.com/papers/6a719f9cce524a4339c51080https://doi.org/10.1371/journal.pone.0010269
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