Key result
Noxious cold stimulation in healthy volunteers revealed a trimodal probability density distribution of pain responses, with mean thresholds at 25.9, 18.4, and 8.0 °C for tonic stimuli.
Observational (n=148)
Data-driven computational approaches identified reproducible subgroups of healthy subjects with distinct patterns of sensitivity to cold stimuli, hinting at different underlying molecular mechanisms.
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Supports data-driven pain phenotyping in healthy subjects; leaves open clinical relevance and molecular validation in patients.
Weyer-Menkhoff et al. (2018) conducted an observational in Healthy subjects (n=148). Noxious cold stimulation was evaluated on Pain thresholds to noxious cold stimuli. Noxious cold stimulation in healthy volunteers revealed a trimodal probability density distribution of pain responses, with mean thresholds at 25.9, 18.4, and 8.0 °C for tonic stimuli.
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