Pathological effects of alcohol septal ablation for hypertrophic obstructive cardiomyopathy
Why the study?
What are the pathological effects of intracoronary ethanol administration for alcohol septal ablation in patients with HOCM?
Population
4 patients with hypertrophic obstructive cardiomyopathy who underwent surgical septal myectomy 2 days to 14…
Design
Case_series
Follow-up
2 days to 14 months
Authors
Discussion
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Member takes
Implication
Ethanol ablation produces direct vascular-myocardial necrosis distinct from thrombosis; leaves open whether this mechanism informs procedural refinements in HOCM.
Structured PICO
What are the pathological effects of intracoronary ethanol administration for alcohol septal ablation in patients with HOCM?
P
Population
4 patients with hypertrophic obstructive cardiomyopathy (HOCM) who underwent surgical septal myectomy 2 days to 14 months after unsuccessful alcohol septal ablation (ASA)
I
Intervention
Intracoronary administration of ethanol (alcohol septal ablation)
O
Outcome
Pathological effects on surgical and autopsy specimenssurrogate
Intracoronary ethanol for alcohol septal ablation causes acute myocardial infarction with direct vascular necrosis, distinguishing it from atherosclerotic infarction.
Cite This Study
Baggish et al. (2006) studied this question.