June 1, 2001AJP Heart and Circulatory Physiology

Gap junctional communication underpins EDHF-type relaxations evoked by ACh in the rat hepatic artery

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Population

Rat hepatic artery and A7r5 cells expressing Cx40 and Cx43

Design

Preclinical

Authors

ACAndrew ChaytorUniversity of California, Los Angeles PMPatricia E. MartinLockheed Martin (United States)DED. H. EdwardsCancer Research UK

Discussion

Member takes

Implication

Hypothesis-generating for connexin-targeted vascular therapies in animals; leaves open translation to human EDHF responses without further study.

Structured PICO

Population

Rat hepatic artery and A7r5 cells expressing Cx40 and Cx43

Intervention

Synthetic peptides homologous to Gap 26 and Gap 27 domains of vascular connexins (37,40Gap 26, 43Gap 26, 37,43Gap 27, and 40Gap 27) individually (600 microM) or in combination (300 microM each)

Outcome

EDHF-type relaxations to ACh and intercellular diffusion of Lucifer yellowsurrogate

Direct intercellular communication via gap junctions constructed from Cx37, Cx40, and Cx43 underpins EDHF-type responses in the rat hepatic artery.

Cite This Study

Chaytor et al. (2001) studied this question.

synapsesocial.com/papers/6a71a06a2163a0a01bc5b147 https://doi.org/10.1152/ajpheart.2001.280.6.h2441

View Full Paper

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Implication

Hypothesis-generating for connexin-targeted vascular therapies in animals; leaves open translation to human EDHF responses without further study.

Gap junctional communication underpins EDHF-type relaxations evoked by ACh in the rat hepatic artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Gap junctional communication underpins EDHF-type relaxations evoked by ACh in the rat hepatic artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider