September 1, 1994The Journal of General PhysiologyOpen Access

Evidence for a direct interaction between internal tetra-alkylammonium cations and the inactivation gate of cardiac sodium channels.

View Full Paper

Ask AI

Bookmark

Population

human cardiac sodium channels (hH1) expressed in a mammalian tsA201 cell line

Design

Preclinical

Authors

MOMichael E. O’LearyCooper Medical School of Rowan University RKRoland G. KallenElectrophysiology RHR HornZoological Society of San Diego

Discussion

Member takes

Implication

May inform Na channel modulator design; leaves open clinical translation from animal models.

Structured PICO

Population

human cardiac sodium channels (hH1) expressed in a mammalian tsA201 cell line

Intervention

Internal tetrabutylammonium (TBA) and tetrapentylammonium (TPeA)

Outcome

Macroscopic Na current inactivation rate and use-dependent blocksurrogate

TBA and TPeA interact directly with the cytoplasmic inactivation gate of cardiac sodium channels, causing concentration-dependent increases in inactivation rates and use-dependent block.

Cite This Study

O’Leary et al. (1994) studied this question.

synapsesocial.com/papers/6a71a0cb439bab0cabc3a23f https://doi.org/10.1085/jgp.104.3.523

View Full Paper

Ask AI

Bookmark

Evidence for a direct interaction between internal tetra-alkylammonium cations and the inactivation gate of cardiac sodium channels.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evidence for a direct interaction between internal tetra-alkylammonium cations and the inactivation gate of cardiac sodium channels.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider