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February 5, 2015Cardiology and TherapyOpen Access

Long-Term Use of Antihypertensive Agents and Risk of Breast Cancer: A Population-Based Case–Control Study

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Why the study?

Does long-term use of antihypertensive agents increase the risk of breast cancer in women with hypertension?

Population

330,699 Taiwanese women with hypertension treated with antihypertensive drugs between January 1, 1998 and…

Comparison

Long-term use of antihypertensive agents vs Non-use or other antihypertensive drugs

Design

Case-control

Follow-up

up to 13 years

Authors

HLHenry W. C. LeungChina Medical UniversityLHLi‐Ling HungHsin Sheng College of Medical Care and ManagementACAgnes L. F. ChanChina Medical University

Discussion

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Member takes

Implication

No change to antihypertensive prescribing indicated; leaves open causality and needs prospective confirmation.

Structured PICO

Does long-term use of antihypertensive agents increase the risk of breast cancer in women with hypertension?

P
Population
330,699 Taiwanese women with hypertension treated with antihypertensive drugs between January 1, 1998 and December 31, 2011
I
Intervention
Long-term use of antihypertensive agents (including beta-1 selective beta-blockers and calcium channel blockers)
C
Comparator
Non-use or other antihypertensive drugs (adjusted for other types of antihypertensive drugs, statins and co-morbidities)
O
Outcome
Risk of breast cancersafety

Long-term use of calcium channel blockers and beta-1 selective beta-blockers may be associated with a slightly increased risk of breast cancer in women with hypertension.

Cite This Study

Leung et al. (2015) studied this question.

synapsesocial.com/papers/6a71a10b53da1ffdb507c1d8https://doi.org/10.1007/s40119-015-0035-1
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