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August 10, 2016PLoS ONEOpen Access

The Use of Antihypertensive Medication and the Risk of Breast Cancer in a Case-Control Study in a Spanish Population: The MCC-Spain Study

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Why the study?

Does long-term use of antihypertensive drugs increase the risk of breast cancer in women?

Population

3,631 women (1,736 breast cancer cases and 1,895 healthy controls) in a Spanish population

Comparison

Long-term use of antihypertensive drugs vs Nonusers of antihypertensive drugs

Design

Case-control

Authors

IGInés Gómez‐AceboInstituto de Salud Carlos IIITDTrinidad Dierssen‐SotosUniversidad de CantabriaCPCamilo Palazuelos

Discussion

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Member takes

Implication

Should not change CCB prescribing; leaves open need for prospective confirmation of breast cancer risk.

Structured PICO

Does long-term use of antihypertensive drugs increase the risk of breast cancer in women?

P
Population
3,631 women (1,736 breast cancer cases and 1,895 healthy controls) in a Spanish population
I
Intervention
Long-term use (≥5 years) of antihypertensive drugs (calcium channel blockers, angiotensin II receptor blockers, ACE inhibitors, beta blockers, diuretics)
C
Comparator
Nonusers of antihypertensive drugs
O
Outcome
Risk of breast cancersafety

Long-term use of calcium channel blockers may be associated with an increased risk of certain breast cancer subtypes, particularly in overweight women.

Cite This Study

Gómez‐Acebo et al. (2016) studied this question.

synapsesocial.com/papers/6a927ad29da65ccb7849fa47https://doi.org/10.1371/journal.pone.0159672

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prospective Study of Calcium Channel Blocker Use, Cardiovascular Disease, and Total Mortality Among Hypertensive Women1998 · 44 citations
  2. 2Angiotensin-Converting Enzyme Inhibitors, Calcium Channel Blockers, and Breast Cancer2000 · 116 citations
  3. 3Long-Term Use of Antihypertensive Agents and Risk of Breast Cancer: A Population-Based Case–Control Study2015 · 32 citations
  4. 4Calcium-channel blockers and risk of cancer1997 · 194 citations
  5. 52013 ESH/ESC Guidelines for the management of arterial hypertension2013 · 13,686 citations