Activation of melanocytes in idiopathic guttate hypomelanosis after 5-fluorouracil infusion using a tattoo machine: Preliminary analysis of a randomized, split-body, single blinded, placebo controlled clinical trial

To the Editor: This letter presents a preliminary analysis of the first 8 patients who have completed a randomized clinical trial for idiopathic guttate hypomelanosis (IGH) treatment that was approved by the respective ethics committee and registered in the ClinicalTrials.gov database under identifier NCT02904564. The rationale for this study was the preliminary histologic analysis of IGH spots in which we observed varying degrees of papillary dermis fibrosis.1 Fulton et al2 described the repigmentation of hypopigmented scars arising from different etiologies after mechanical removal of dermal fibrosis.